This book reviews macrocycles in drug discovery both those of natural origin and semi synthetic derivatives of natural products and those designed and synthesized based on principles of medicinal chemistry. Macrocycles have demonstrated repeated success when addressing targets that have proved to be highly challenging for standard small molecule drug discovery especially in modulating macromolecular. Up to 90 off textbooks at amazon canada plus free two day shipping for six months when you sign up for amazon prime for students. Macrocycles in drug discovery have been defined as a ring system consisting of 12 or more atoms opinions differ on the definition of macrocycles based on ring size but this option usefully captures the qualitative differences in behavior between large macrocyclic rings 12 atoms and medium rings 8 11 atoms. Returning to one of the primary drivers for the pursuit of macrocycles in drug discovery the potential to address intractable targets such as ppi the unique and versatile nature of the macrocyclic framework again has been demonstrated with increasing reports of successful modulation of this target class with these molecules although such applications are still too early stage to gauge their
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